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Phenergan (Promethazine)

Buy Promethazine Without Prescription

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About Promethazine

Promethazine is used to prevent and treat nausea and vomiting related to certain conditions (such as motion sickness, or before/after surgery). It is also used to treat allergy symptoms such as rash, itching, and runny nose. It may be used to help you feel sleepy/relaxed before and after surgery or to help certain narcotic pain relievers (such as meperidine) work better. The suppository form is used when medications cannot be taken by mouth. Promethazine is an antihistamine and works by blocking a certain natural substance (histamine) that your body makes during an allergic reaction.


Promethazine is used to prevent and treat nausea and vomiting related to certain conditions (such as motion sickness, or before/after surgery). It is also used to treat allergy symptoms such as rash, itching, and runny nose. It may be used to help you feel sleepy/relaxed before and after surgery or to help certain narcotic pain relievers (such as meperidine) work better. The suppository form is used when medications cannot be taken by mouth. Promethazine is an antihistamine and works by blocking a certain natural substance (histamine) that your body makes during an allergic reaction. Its other effects (such as anti-nausea, calming, pain relief) may work by affecting other natural substances (such as acetylcholine) and by acting directly on certain parts of the brain.

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How to use

  • Unwrap and insert one suppository rectally as directed by your doctor, usually 2 to 4 times daily.
  • Remain lying down for a few minutes after using this medication, and avoid having a bowel movement for an hour or longer so the drug will be absorbed. The suppository is for rectal use only.
  • For motion sickness, the first dose of promethazine should be used 30 to 60 minutes before beginning travel.
  • For allergies, this medication may be used once daily at bedtime to avoid being drowsy during the day. When used before surgery, promethazine may be used the night before or just before the procedure and may be continued afterwards as directed.

The dosage is based on your age, medical condition, and response to treatment. In children, the dosage may also be based on weight. Do not increase your dose or use this medication more often than directed. Tell your doctor if your condition does not improve or if it worsens.

Side Effects

  • Nausea
  • Drowsiness
  • Dizziness
  • Dry mouth
  • Constipation
  • Loss of appetite
  • Blurred vision
  • Nervousness
  • Trouble sleeping
  • Unusual sweating
  • Yawning may occur

If any of these effects persist or worsen, tell your doctor promptly. Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. This medication may raise your blood pressure. Check your blood pressure regularly and tell your doctor if the results are high.

Tell your doctor right away if any of these unlikely but serious side effects occur:

  • easy bruising/bleeding
  • decreased interest in sex
  • changes in sexual ability
  • muscle cramps/weakness
  • shaking (tremor)

Get medical help right away if any of these rare but serious side effects occur:

  • cough that doesn’t go away
  • shortness of breath
  • chest pain
  • severe/pounding headache
  • black/bloody stools
  • vomit that looks like coffee grounds
  • eye pain/swelling/redness
  • widened pupils
  • vision changes (such as seeing rainbows around lights at night)
  • seizure

This medication may increase serotonin and rarely cause a very serious condition called serotonin syndrome/toxicity. The risk increases if you are also taking other drugs that increase serotonin, so tell your doctor or pharmacist of all the drugs you take (see Drug Interactions section).

Get medical help right away if you develop some of the following symptoms:

  • fast heartbeat
  • hallucinations
  • loss of coordination
  • severe dizziness
  • severe nausea/vomiting/diarrhea
  • twitching muscles
  • unexplained fever
  • unusual agitation/restlessness.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including:

  • rash
  • itching/swelling (especially of the face/tongue/throat)
  • severe dizziness
  • trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.


Before using promethazine, tell your doctor or pharmacist if you are allergic to it; or to any other phenothiazines (such as prochlorperazine); or if you have any other allergies.

This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details. Before using this medication, tell your doctor or pharmacist your medical history, especially of:

  • breathing problems (such as asthma, chronic obstructive pulmonary disease-COPD, sleep apnea)
  • blood/immune system problems (such as bone marrow depression)
  • high pressure in the eye (glaucoma)
  • heart disease (such as irregular heartbeat)
  • high blood pressure
  • liver disease
  • certain brain disorders (such as neuroleptic malignant syndrome
  • Reye’s syndrome, seizures)
  • stomach/intestine problems (such as blockage, ulcer)
  • overactive thyroid (hyperthyroidism)
  • difficulty urinating (for example, due to enlarged prostate)

This drug may make you dizzy or drowsy or blur your vision. Alcohol or marijuana (cannabis) can make you more dizzy or drowsy. Do not drive, use machinery, or do anything that needs alertness or clear vision until you can do it safely. Avoid alcoholic beverages. Talk to your doctor if you are using marijuana (cannabis). Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

This medication may make you more sensitive to the sun. Limit your time in the sun. Avoid tanning booths and sunlamps. Use sunscreen and wear protective clothing when outdoors. Tell your doctor right away if you get sunburned or have skin blisters/redness.

This medication may make you sweat less, making you more likely to get heat stroke. Avoid doing things that may cause you to overheat, such as hard work or exercise in hot weather, or using hot tubs. When the weather is hot, drink a lot of fluids and dress lightly. If you overheat, quickly look for a place to cool down and rest. Get medical help right away if you have a fever that does not go away, mental/mood changes, headache, or dizziness.

Children may be more sensitive to the side effects of this drug, especially slowed breathing (see Warning section). This drug can often cause excitement in young children instead of drowsiness. Special care should be taken when using this medication in children who have lost a lot of fluid (dehydration), those who have a family history of sudden infant death syndrome (SIDS), and those who are hard to wake up from sleep.

Older adults may be more sensitive to the side effects of this drug, especially drowsiness, confusion, constipation, or trouble urinating. Drowsiness and confusion can increase the risk of falling.

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor. It is unknown if promethazine passes into breast milk. It may have undesirable effects on a nursing infant. Consult your doctor before breast-feeding.

How to store

  1. Store in the refrigerator.
  2. Do not freeze.
  3. Keep all medications away from children and pets.
  4. Do not flush medications down the toilet or pour them into a drain unless instructed to do so.
  5. Properly discard this product when it is expired or no longer needed.

Consult your pharmacist or local waste disposal company.

Drug Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor’s approval.

Some products that may interact with this drug include: antihistamines applied to the skin (such as diphenhydramine cream, ointment, spray), metoclopramide. The risk of serious side effects (such as slow/shallow breathing, severe drowsiness/dizziness) may be increased if this medication is used with other products that may also cause drowsiness or breathing problems.

Tell your doctor or pharmacist if you are taking other products such as opioid pain or cough relievers (such as codeine, hydrocodone), alcohol, marijuana (cannabis), drugs for sleep or anxiety (such as alprazolam, lorazepam, zolpidem), muscle relaxants (such as carisoprodol, cyclobenzaprine), or other antihistamines (such as cetirizine, diphenhydramine).


This medicine may be harmful if swallowed. If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call the emergency services. Otherwise, call a poison control center right away. Canada residents can call a provincial poison control center. Symptoms of overdose may include: severe drowsiness/dizziness, fainting, slow/shallow breathing, seizures, muscle stiffness/twitching, widened pupils. In children, mental/mood changes (such as restlessness, irritability, hallucinations) may occur before drowsiness.

Frequently Asked Questions

Last Updated on July 20, 2021 by admin

The content of this website is for informational purposes only and is not intended as a substitute for professional medical advice, diagnosis or treatment. Please seek the advice of a physician or other qualified health care provider with any questions you may have regarding a medical condition. Do not disregard professional medical advice or delay in seeking it because of something you have read on this website.
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Important product details

  • Commercial Name: Phenergan
  • Principal Ingredient: Promethazine
  • Production form: Pills
  • Utilization: Treats allergies / Passing Insomnia
  • Available Dosage: 25mg


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